Buffalo Bills vs. Tennessee Titans picks, predictions: Who wins NFL Week 6 game?

Jeremy Cluff
Arizona Republic

The Buffalo Bills and Tennessee Titans face off on Monday in a Week 6 NFL game.

Which team will get the victory?

Check out these NFL Week 6 picks and predictions for the game, which can be seen at 5:15 p.m. MST time on ESPN.

The Bills are a 3.5-point favorite in the game.

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Pro Football Network: Bills 31, Titans 24

Ben Rolfe writes: "The Bills just put on a dominating performance against the Chiefs and will roll into Tennessee feeling confident. However, big statement victories can often be followed by a letdown game. The Bills cannot afford that against a Titans team that has failed to impress this season. One concern for Buffalo could be the success Patrick Mahomes and Darrel Williams had on the ground in Week 5. If Ryan Tannehill and Derrick Henry get rolling, this could be a tough game. Tennessee humiliated the Bills last season, but Buffalo’s defense looks drastically different in 2021."

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Sportsnaut: Bills 34, Titans 23

Vincent Frank writes: "If you’re looking for a high-scoring affair, this season’s matchup between the Bills and Titans should deliver. Both teams don’t have an elite pass rush, which is dangerous against offenses like the ones they will each face. Playing in front of a big crowd might give Tennessee a boost, but the better team and top talent usually comes out on top."

Bills Wire: Titans will beat Bills in Week 6

Nick Wojton writes: "A trip up for the Bills after topping the Chiefs in this scenario. The Titans got the best of the Bills just a year ago in a big way and their offense is crazy explosive."

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Will Josh Allen lead the Buffalo Bills past the Tennessee Titans in Week 6 of the 2021 NFL season?

Fansided: Bills 27, Titans 23

Geoffrey Knox writes: "Things get very serious in Week 6 as the Tennessee Titans get the Buffalo Bills in Week 6. This one doubles as Tennessee’s first primetime game of the season. "

Sportsnaut: Bills 35, Titans 21

Matt Johnson writes: "For the Tennessee Titans to have any shot of beating Buffalo on Monday Night Football, Derrick Henry needs to have a 200-yard game. If the Titans’ offense doesn’t sustain long drives, MVP candidate Josh Allen is going to pick one of the league’s worst defenses apart. Ultimately, that’s how we see this game unfolding."

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Fansided: Bills will lose to Titans in Week 6

Brandon Croce writes: "This game looks like it will be shaping up to be a shootout as the Titans defense has concerns in their secondary and the Bills have one of the top passing attacks in the game. This is one of those games where whoever has the ball last will win."

FiveThirtyEight.com: Bills have a 65% win probability

The site gives the Titans a 35% win probability in the NFL Week 6 game.

ESPN: Bills have a 72.3% chance to win

The site's Football Power Index gives the Titans a 27.5% chance to pick up the victory in the Week 6 NFL game.

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