Dallas Cowboys at Los Angeles Chargers odds, picks and prediction

Jess Root
Sportsbook Wire

The Dallas Cowboys (0-1) are on the road Sunday for the second week in a row as they face the Los Angeles Chargers (1-0), who are playing their home opener. Kickoff is set for 4:25 p.m. ET at SoFi Stadium. Below, we look at the Cowboys at Chargers odds and lines, and make our best NFL picks, predictions and bets.

The Cowboys lost 31-29 at the defending champion Tampa Bay Buccaneers on a last-second field goal in Week 1. QB Dak Prescott threw for 403 yards with 3 touchdowns, while the defense forced 4 Tampa Bay turnovers, but it wasn't enough.

The Chargers won their season opener, defeating the Washington Football Team 20-16. Statistically, they dominated the game. They outgained Washington 424-259 yards, they were 14-for-19 on third downs and monopolized the time of possession 36:03 to 23:57.

However, they turned the ball over twice, making the game much closer. QB Justin Herbert passed for 337 yards with a touchdown and an interception.

Also see:All Week 2 odds and lines

Cowboys at Chargers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports' betting odds for a full list. Lines last updated Friday at 9:02 a.m. ET.

  • Money line: Cowboys +145 (bet $100 to win $145) | Chargers -180 (bet $180 to win $100)
  • Against the spread (ATS): Cowboys +3.5 (-115) | Chargers -3.5 (-107)
  • Over/Under (O/U): 54.5 (O: -115 | U: -105)

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Cowboys at Chargers key injuries

Cowboys

  • S Damontae Kazee (thigh) questionable
  • DE Demarcus Lawrence (foot) out
  • S Donovan Wilson (groin) questionable

Chargers

  • S Nasir Adderley (groin) questionable
  • OT Bryan Bulaga (groin/back) questionable
  • CB Chris Harris (shoulder) questionable
  • DL Justin Jones (calf) questionable
  • K Tristan Vizcaino (illness) questionable

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Cowboys at Chargers odds, lines, predictions and picks

Prediction

Chargers 31, Cowboys 20

Money line

The Chargers have both an explosive offense and a tough defense. With Dallas expected to be missing some defensive starters, Los Angeles will be able to put points on the scoreboard. While Dallas can score, it will struggle some against the Chargers defense.

Dating back to last season, the Chargers have won five straight games.

Take the CHARGERS (-180).

Against the spread

The Chargers have also covered the spread in their last five games, dating back to last season.

The Cowboys have covered the spread in four of their last five. However, they are 1-4 ATS in their last five September games.

Take the CHARGERS -3.5 (-107).

Over/Under

With a total this high, one team will have to either score in the 40s or have both teams get into the high 20s in a close game.

The Chargers will be able to score. I anticipate them getting into the 30s against a depleted Cowboys defense. However, the Chargers defense will limit Dallas enough to stay in control.

Take UNDER 54.5 (-105).

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